NFKB1 and myeloid sarcoma: TLR ligands were identified as T-cell promoters in MS, and the expression of NF-κB DNA-binding activity was elevated in macrophages of MS patients after stimulation with TLR ligands, while upregulation of NF-κB-controlled adhesion molecules and cytokines could lead to an enhanced inflammatory response (Chen, Szodoray & Zeher, 2016).