Multifactor logistic regression analysis showed that age (OR = 0.809, p < .001), age ≥75 years (OR = 11.482, p = .007), admission time (OR = 1.587, p < .001), HsCRP (OR = 0.397, p < .001), NTpro‐BNP (OR = 0.996, p < .001), LEVF (OR = 1.123, p = .016), and distribution of infarct hemisphere (OR = 27.241, p = .035) are independently risk factors between the NVAF+ICAS and ICAS groups. The gene discussed is NPPB; the disease is familial isolated congenital asplenia.