Recently, we found that the integrity of the gut barrier was markedly decreased in Tg2576 AD mice which might increase bacterial amyloid (curli) burden in the gut before the appearance of Aβ deposition in the brain.87 Curli stimulated TLR2 activation and co-localized with neuroendocrine marker PGP 9.5 within the epithelium and sub-mucosa of the gut in AD mice.87 It indicated the vagus nerve activation by bacterial curli. The gene discussed is TLR2; the disease is Alzheimer disease.