APP and Alzheimer disease: SLAB51 treatment ameliorated brain damage with improved cognition and reduced levels of Aβ through the fractional recovery of ubiquitin-proteasome system and autophagy pathways.125 Te ́gla ́s et al. also found that using probiotic supplementation (with Bifidobacterium longum and Lactobacillus acidophilus) for twenty weeks, delayed the progression of AD in 3-month old, male APP/PS1 transgenic mice.