Oxidative stress can accelerate the aggregation of Aβ and vice versa.4,26 Additionally, hyperphosphorylated tau proteins may lead to reduced activity of NADH-ubiquinone reductase enzyme, increasing ROS production and mitochondrial dysfunction in AD.32 Therefore, the relationship between oxidative stress and AD (Figure 2) is well documented in previous studies which indicate the importance of the antioxidant defense system in the brain. Here, MAPT is linked to Alzheimer disease.