Further, ST analysis revealed concordant differential distribution of tumor cells and accessory cell types within these territories with higher frequency of tumor cells, basophils/mast cells, neutrophils and MSCs in IC territories and a high frequency of T cells/type 2 innate lymphoid cells (ILC2s), natural killer (NK) cells, conventional dendritic cells (cDCs), monocytes and alveolar macrophages in IFN territories (Fig. 4f). This evidence concerns the gene IFNA1 and neoplasm.