PTPRC and neoplasm: According to the morphological differences and the above markers, the selected micro-regions were annotated as: (1) tumor islets, (2) necrotic, (3) stroma (with variable contributions of tumor cells and immune cells), (4) CD45+ (immune) cell rich, (5) tertiary lymphoid structures (TLSs) and (6) other (including blood vessels and nonmalignant lung) (Fig. 3d, Supplementary Fig. 1 and Supplementary Table 5).