Specifically in tumor micro-regions, the expression of the immune-related genes18CCL5, CD27 (PD-L1), CD8A, CMKLR1, CXCL9, CXCR6, IDO1, LAG3, NKG7, PDCD1LG2 (PD-L2), PSMB10 and STAT1 followed the profile of CD45, supporting our classification (Fig. 3g and Extended Data Fig. 3a,b). This evidence concerns the gene CD8A and neoplasm.