CD8A and neoplasm: Indeed, correlating the GeoMx gene expression profiles of each tumor micro-region and the respective patient macro-regions’ bulk RNA-seq data revealed increasing variation (calculated as variance of correlation coefficients) from tumors marked as CD3+CD8+ T cell-infiltrated-low (02290, better mirror), CD3+CD8+ T cell-infiltrated-high (03023 and 02672), CD3+CD8+ T cell-excluded-high (02289, 02671 and 03421) and CD3+CD8+ T cell-excluded-low (02287 and 02288, poor mirror) (Student’s t-test P = 0.082; Fig. 3h–j), supporting our classification above.