PTPRC and neoplasm: Gene ontology (GO) enrichment analysis of genes overexpressed (z-score > 2) in tumor micro-regions of the two above HLA-II+ cases (patients 03421 and 02672), relative to all other patients, revealed a significant enrichment for genes associated with processing and presentation of exogenous antigens on HLA-II and on HLA-I, whereas terms related to cell cycle, regulation of transcription and cellular response to DNA damage were mostly enriched in HLA-II− tumors (Fig. 4h); however, these differences were not obvious when stroma, CD45+ and TLS micro-regions were analyzed (Fig. 4h).