It is interesting that the HLA-II peptidome (represented by the presentation of these source genes) of infiltrated-high samples was associated with the presence of CD8+ T cells, cytotoxic T cells and exhausted CD8+ T cells in the tumor micro-regions, as well as most of the other immune cell types in the stroma, TLS and CD45+ micro-regions (Fig. 5j). This evidence concerns the gene CD8A and neoplasm.