CXCL8 and non-small cell lung carcinoma: Despite that it remains controversial about the role of miR-182 in lung tumor occurrence and development [27, 28], our data indicate miR-182 as a critical regulator in NSCLC cells for bone metastasis and further demonstrate that miR-182 promotes NSCLC cell-induced osteolysis and metastatic burden by enhancing IL-8 secretion.