Our mechanistic studies revealed that miR-182 enhanced IL-8 expression in NSCLC cells by targeting the NF-κB signaling inhibitor gene KLHL21 [29], and thus increased IL-8 secretion from NSCLC cells to facilitate osteoclastogenesis via activating STAT3 signaling in osteoclast progenitor cells. Here, KLHL21 is linked to non-small cell lung carcinoma.