Moreover, recent studies on breast cancer cells report that tumor-derived Jagged1 promotes osteoclast formation and bone absorption by activating the Notch signaling pathway in osteoclasts [9], while cancer cell secreted-IL-11 functions as a pro-osteolytic factor by activating the JAK1/STAT3 pathway in osteoclast progenitor cells [10, 11]. The gene discussed is STAT3; the disease is cancer.