By co-staining of MMP9 and CTSK, and K8, we found that MMP9 level was elevated in CTSK-positive cells at the tumor-bone boundary of the miR-182-OE lesions compared with the control group (Fig. S3C), further confirming the increase of osteoclastogenesis at the tumor-bone boundary. The gene discussed is CTSK; the disease is neoplasm.