If human SMCHD1 missense mutations do in fact act in a gain-of-function manner16, an increase in Smchd1 expression driven by higher glucose could conceivably exacerbate the phenotype, whereas a decrease in expression during chondrogenesis could create a milder phenotype (e.g., nasal hypoplasia or anosmia). The gene discussed is SMCHD1; the disease is Short nose.