PML NBs are involved in chromatin remodeling, the regulation of transcription (e.g., of IFN genes) [83–86], DNA damage responses, the suppression of tumor growth, senescence, apoptotic responses, the regulation of cell cycle progression antiviral defenses, reviewed in [17, 87–89] and the regulation of the alternative lengthening of telomeres, reviewed in [90]. Here, PML is linked to neoplasm.