The MPO activity of the SLN-BUD-2L group was significantly reduced from 1.702 U/g tissue (colitis group) to 0.791 U/g tissue, exhibiting superiority over those of the free BUD (1.145 U/g tissue) and SLN-BUD (1.300 U/g tissue) groups (Fig. 6B). The gene discussed is MPO; the disease is colitis.