TFB1M and hydrops fetalis: The list of CDS disrupting SVs contained three high impact SVs: (i) a predicted loss-of-function event by a 3.3-Kb deletion ablating FANCI gene, causing foetal death and brachyspina [23], (ii) a predicted loss-of-function event by a 138-Kb deletion ablating TFB1M gene, which was associated with a lethal haplotype mapped in HF population [24], and (iii) an intragenic exonic duplication event by a 12-Kb mCNV overlapping with the last exon of GC gene, associated with mastitis resistance [17].