In the present study, a total of 12 DEIRGs associated with DKD were identified, including 3 upregulated DEIRGs (CCL19, IL7R, and TRBC1) and 9 downregulated DEIRGs (GHR, FGF1, FYN, VEGFA, F2R, TGFBR3, PTGDS, FGF9, and SEMA5A). This evidence concerns the gene PTGDS and diabetic kidney disease.