IGFBP7 and acute kidney injury: Notably, urine insulin-like growth factor binding protein-7 (IGFBP-7) × tissue inhibitor of metalloproteinase-2 (TIMP-2), a novel indicator of acute kidney injury (Vijayan et al. 2016; Kashani et al. 2013; Wang et al. 2017;), was significantly higher in the Cirp−/− group than in the DHCA group (Fig. 1J).