For example, Gal-9 suppresses antigen-specific CD8+ T cell effector functions via the interaction with its receptor, TIM-3 (Sehrawat et al., 2010), and the Gal-9/TIM-3 axis promotes tumor survival through the cross-talk with the PD-1 immune checkpoint (Yang et al., 2021). The gene discussed is HAVCR2; the disease is neoplasm.