MRC1 and Insulin resistance: In addition to the mechanisms discussed above, a possibility may be that the increased adipose tissue inflammation (3), including a Cd11c-/Cd206+ cell population (an adipose tissue macrophage population expressing scavenger receptors in humans; (9)) and a reciprocal decrease in Cd11c+/Cd206+ double-positive cells (an antigen-presenting lipid-loaded adipose tissue macrophage population in humans; (9)), and higher numbers of T and B cells could contribute to insulin resistance.