Through cis-MR of plasma pQTLs, we identified seven proteins that affected PFR as well as HF or DCM risk: UD16, MANBA, TNR5, TNF12, MFGM, CPC5, and BAG3, where the last five proteins were (indirectly) drugged or druggable, providing leads for drug development (Table 1). The gene discussed is MANBA; the disease is familial dilated cardiomyopathy.