Specifically, higher levels of IL8 (interleukin-8) increased LV-EDM, improved RV-PER, and decreased the risk of AF (OR, 0.83; 95% CI, 0.77 to 0.89), as well as HF (OR, 0.74; 95% CI, 0.69 to 0.81). The gene discussed is CXCL8; the disease is atrial fibrillation.