Higher levels of TDGF1 improved LV and RV cardiac traits (EF, SV, PER, and RV-PFR) and increased the risk of AF (OR, 1.01; 95% CI, 1.01 to 1.01) while decreasing the risk of non-ischemic CM (OR, 0.93; 95% CI, 0.92 to 0.94). This evidence concerns the gene CRIPTO and atrial fibrillation.