To monitor AKT activity in the context of pancreatic cancer progression, the biosensor mouse was crossed to the KRasG12D/+;Pdx1-Cre (KC) or KRasG12D/+;p53R172H/+;Pdx1-Cre (KPC) models of PDAC, respectively. This evidence concerns the gene PDX1 and familial pancreatic carcinoma.