After characterization and purity check, we conducted high-content screening of the DPUDs (DPUD-1 to -23) at 10 μM concentration against two IAV strains (A/X-31, H3N2 and A/WSN/1933, H1N1) and the SARS-CoV-2 Wuhan strain with the D614G mutation in the S glycoprotein (hereafter called the D614G strain) using cell-based infection assays. Here, ART4 is linked to infection.