Notably, the PTPN11 (c.1507G>A and c.1508G>T), KRAS (c.35G>A and c.35G>T), and BRAF (c.1797A>G and c.1799T>A) variants are all located in mutational hot spots for cancer and neurodevelopmental disorders.19,20,21 However, except for KRAS c.35G>T and BRAF c.1799T>A, which have been reported in FCDs22,23 and LEATs,24 to our knowledge, none of the other somatic variants have been previously described in focal epilepsies. This evidence concerns the gene PTPN11 and neurodevelopmental disorder.