While the contribution of somatic variants to MTLE has not been previously described, to our knowledge, most FCD-associated somatic variants reported to date are in PI3K/Akt/mTOR pathway genes,15 whereas LEAT-associated variants often involve the Ras/Raf/MAPK pathway.24 To further investigate the association between somatic genotype and brain regional specificity, we performed a focused retrospective review of the FCD and LEAT literature. This evidence concerns the gene MTOR and fleck corneal dystrophy.