For example, the notion that head and neck muscles, together with the heart, are affected in DiGeorge syndrome indicates that they emerge from the Tbx1-expressing CPF (Diogo et al., 2015; Greulich et al., 2011; Lescroart et al., 2015; Swedlund and Lescroart, 2019). The gene discussed is TBX1; the disease is 22q11.2 deletion syndrome.