Backward elimination in the final logistic regression and validated weighted transformation procedure resulted in: HELP scale = (functional status × 11) + (ascites × 3) + (SBP × 3) + (HE × 4) + (dialysis × 5) + (TIPS × −3) + (albumin × −3) + (MELD‐Na ≥ 21 × 20). The gene discussed is ALB; the disease is Ascites.