Salidroside (Sal) can not only reduce and inhibit pyroptosis through accumulation of Aβ and phosphorylation of Tau through downregulation of IL‐1β and IL‐18 expression, in addition, Sal reversed the increase in the protein expression of TLR4, NF‐κB, NLRP3, ASC, cleaved caspase‐1, cleaved GSDMD, IL‐1β, and IL‐18 in AD mouse model.309. Here, IL18 is linked to Alzheimer disease.