Salidroside (Sal) can not only reduce and inhibit pyroptosis through accumulation of Aβ and phosphorylation of Tau through downregulation of IL‐1β and IL‐18 expression, in addition, Sal reversed the increase in the protein expression of TLR4, NF‐κB, NLRP3, ASC, cleaved caspase‐1, cleaved GSDMD, IL‐1β, and IL‐18 in AD mouse model.309. The gene discussed is IL1B; the disease is Alzheimer disease.