Furthermore, silencing of CMKLR1 with siRNA improves the function of cardiac in a Sprague–Dawley rat model of DCM induced by HFD and low dose of streptozotocin (STZ) by attenuating cardiac inflammation and cardiomyocyte pyroptosis, indicating that pyroptosis is an important protective target of DCM.176. This evidence concerns the gene CMKLR1 and familial dilated cardiomyopathy.