Though some previous studies using 16S rRNA-based phylogeny have also demonstrated that LBP is potentially related to gut dysbacteria (such as Oxalobacter, Lactobacillus, Prevotella, Roseburia and Eisenbergiella etc.)among Asian population, causal relationship between gut microbiota/metabolites and LBP in people from other regions remain unclear (Rajasekaran et al., 2020; Zhou et al., 2020; Wei et al., 2021; Sugimura et al., 2022). This evidence concerns the gene LBP and Low back pain.