Low-density lipoprotein receptor (LDLR) is regulated by the circadian clock via the complex Clock/Bmal1 (45) In addition, fatty acid binding protein 4 (FABP4,) one of the main lipid-binding proteins in adipose tissue and liver, has been shown to have a circadian expression in both tissues (46) and it is overexpressed in the liver in the contexts of morbid obesity and insulin resistance (47). This evidence concerns the gene CLOCK and Insulin resistance.