Circadian misalignment can also be caused by travelling across several time zones leaving us with sleep problems, fatigue, cognitive impairments, and gastrointestinal issues summarized asjetlag disorder. During jetlag, the body’s internal time is misaligned to local geophysical time, and the circadian clock network needs some time to entrain to the new time zone (Diekman and Bose, 2018;Kiesslinget al., 2010;McGuckinet al., 2014;Roach and Sargent, 2019;Wrightet al., 1983). The gene discussed is CLOCK; the disease is Cognitive impairment.