Two cohort studies assessed the immunogenicity and safety of the HPV vaccinationin 68 children with JIA and 210 children with cSLE treated with NSAIDs,glucocorticosteriods, conventional DMARDs and bDMARDs (TNF inhibitors and IL-1inhibitors), in comparison to 90 controls.28,39. The gene discussed is TNF; the disease is juvenile idiopathic arthritis.