We also treated with IL1β and IL6 as these cytokines are elevated in Parkinson’s disease.5,19–21 The reactive transformation was confirmed following TNFα/IL1α/C1q and IL1β treatments by upregulation of genes known to be associated with the reactive state,5,19 but IL6 treatment was ineffective (Fig. 2A). This evidence concerns the gene IL6 and Parkinson disease.