We also treated with IL1β and IL6 as these cytokines are elevated in Parkinson’s disease.5,19–21 The reactive transformation was confirmed following TNFα/IL1α/C1q and IL1β treatments by upregulation of genes known to be associated with the reactive state,5,19 but IL6 treatment was ineffective (Fig. 2A). The gene discussed is IL1B; the disease is Parkinson disease.