Noteworthy, both GSEA and logistic regression analysis showed that the low-level EPAS1 expression was significantly correlated with FMS-like tyrosine kinase-3 (FLT-3) mutation, which is considered to be one of the most important drivers in AML [36], being associated with poor prognosis in AML [37]. Here, FLT3 is linked to acute myeloid leukemia.