Concerning the effect of APOE*4, our results are in accordance with a follow-up study of 1,871 African Americans, of whom 182 developed dementia, the authors found an HR of 4.12 [2.33–7.28] for APOE*44 carriers compared to APEOE*33; (52) which is similar to or results of 4.66 [2.01–10.81]. This evidence concerns the gene APOE and dementia.