APOE and dementia: Though the proportion of APOE*44 carriers is higher in Black (5.4%) than in the white population (2.3%, p < 0.001, Table 1), the effect of the APOE*44 variant on the risk of incident dementia in the Black population is much smaller than in white population, suggesting there are modifying variants in people of African descent in the UK, as has been found in African Americans (39).