However, a retrospective longitudinal analysis of 10,288 subjects with a mean follow-up of 42.2-70.8 months showed that LDL-C/ApoB and HDL-C/ApoA-1 ratios, but not ApoB concentration, independently predicted an increased risk of developing CKD(eGFR < 60 ml/min/1.73 m2). The gene discussed is APOB; the disease is chronic kidney disease.