INS and type 2 diabetes mellitus: However, Coprococcus_1, found in the T2D treated group, was already characterized by a high insulin sensitivity (β = 0.14; P = 0.002) and disposition index (β = 0.12; P = 0.012); for this reason, we hypothesized that its effect was mostly related to the changes in the constant metformin consumption in T2D patients (89).