Although studies thus far have focused primarily on GPR101 and its role in endocrine related disorders such as X-linked acrogigantism (X-LAG) (54, 55), new emerging studies indicate other possible functions in mediating the hypothalamic control of energy homeostasis, pro-resolving actions in leukocytes to control inflammation, and stimulating cell proliferation and metastatic behavior in endometrial cancer cells (45, 48, 49, 56, 57). Here, GPR101 is linked to endometrial cancer.