Of note, neutralizing CCR4 activity on the endothelial cell surface resulted in a significant decrease in TNFα-stimulated leukocyte adhesion when blood from obese patients was perfused (p=0.0013, Figure 4C) but not when it was from controls, indicating that CCR4 axes play an important role in leukocyte recruitment and endothelial impairment in patients with morbid obesity. The gene discussed is TNF; the disease is morbid obesity.