Currently, research on the role of PKM and GAPDH in the tumor endocrine and glucose metabolism pathways is relatively mature, while there has been less research on the significance of the insulin metabolism pathway, prostaglandin metabolism pathway, and other endocrine pathways in the field of CRC, thus the biological significance of tumor endocrine pathways has deserved more attention in the future. This evidence concerns the gene PKM and colorectal carcinoma.