According to the results of Gene Ontology (GO) analysis, several SNO proteins, such as glutamate dehydrogenase 1 (GLUD1), pyruvate kinase PKM (PKM), and prostaglandin E synthase 3 (PTGES3), might be involved in the metabolic pathways that are important in tumor endocrine biological processes. The gene discussed is PKM; the disease is neoplasm.