The SNO proteins were detected in both SW 480 cells and human cancer tissue, suggesting that these proteins might have important implications in the genesis, progression and apoptosis of CRC, such as nucleoside diphosphate kinase (NME1-NME2), ACTB (Figures 4A–C), and protein S100A8 (S100A8). This evidence concerns the gene NME2 and cancer.