A study by Helmer and co-workers demonstrated that the deletion of the helicase-like transcription factor in the tumor microenvironment of CRC could lead to the trans activation of inducible nitric oxide synthase (iNOS), leading to the reprogramming of SNO sites of tumor proteins in the iNOS-S100 calcium binding protein (S100A8/A9) signaling axis. The gene discussed is NOS2; the disease is neoplasm.