Irene et al. demonstrated that inhibition of the PI3K/AKT pathway reversed progesterone resistance by reducing non-genomic progestogen-mediated reactivation of the PI3K/AKT pathway, upregulated progesterone receptor subtype B transcriptional function and reduced angiogenesis in endometrial cancer (Lee et al., 2016). This evidence concerns the gene AKT1 and endometrial cancer.