Prior studies have confirmed significant overexpression of KIAA1429 in multifarious human cancers, including hepatocellular carcinoma (HCC) (Lan et al., 2019), breast cancer (Qian et al., 2019), non-small cell lung cancer (NSCLC) (Tang et al., 2021), gastric cancer (Miao et al., 2020), and osteosarcoma (Han et al., 2020), which was positively correlated with malignant biological properties while linked to significantly diminished OS of above tumors. This evidence concerns the gene VIRMA and hepatocellular carcinoma.