We found that m6A “writers” METTL3 and KIAA1429 and APA enzymes PCF11 were more predisposed to mutation than additional “writers” in BCa, while mutations of the “writers” CPSF1, ADARB2 and KIAA1429 were proved to be more frequent in hepatocellular carcinoma (HCC) and the mutation frequency of the “writers” ZC3H13, PCF11 and KIAA1429 was the highest in colorectal cancer (CRC) (Qian et al., 2019; Xing et al., 2021). The gene discussed is ENPEP; the disease is hepatocellular carcinoma.