AKT1 and neoplasm: The PI3K-AKT signaling pathway is involved in the occurrence and development of various cancers, and can promote the proliferation and invasion of cancer cells, inhibit apoptosis, and promote tumor angiogenesis, thereby leading to the progression of malignant tumors (Alzahrani, 2019; Ediriweera et al., 2019; Noorolyai et al., 2019).