However, inhibition of SGK1 either by germ-line ablation or dominant-negative inhibition does not lead to a notable pathogenic phenotype under basal conditions and appears to be protective against pathological stress, suggesting that small-molecule inhibitors of SGK1 could be antiarrhythmic in cardiac disease through correction of abnormal INa and a potential therapeutic for LQTS.8 This evidence concerns the gene SGK1 and familial long QT syndrome.