Following univariate regression and LASSO regression analysis, seven prognosis-related genes (LRP1, ANXA5, SERPINE2, ECM1, RBP1, GJA1, FKBP10) were screened to be able to predict the construct prognostic characteristics of bladder cancer patients and to evaluate TME mesenchymal and fibroblast components and treatment response. This evidence concerns the gene SERPINE2 and urinary bladder cancer.