Following univariate regression and LASSO regression analysis, seven prognosis-related genes (LRP1, ANXA5, SERPINE2, ECM1, RBP1, GJA1, FKBP10) were screened to be able to predict the construct prognostic characteristics of bladder cancer patients and to evaluate TME mesenchymal and fibroblast components and treatment response. Here, SERPINE2 is linked to urinary bladder carcinoma.