SOX2 and colorectal cancer: also have revealed that IL-22 derived from CD4+ T cells could increase the stemness and tumorigenic potential of colorectal cancer cells by activation of STAT3 and expression of the histone 3 lysine 79 (H3K79) methyltransferase DOT1L, which correlates with the induction of the core stem cell genes NANOG, SOX2 and Pou5F1 (116).