Molecular mechanism research showed that hsa_circ_0012152 played an important role in leukemia initiation and progression through miR-491-5p/epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK1) or miR-512-3p/EGFR/MAPK1 regulatory axes. The gene discussed is EGFR; the disease is leukemia.