SHPRH and central nervous system cancer: Furthermore, a circular transcript from the SNF2 histone linker PHD RING helicase (SHPRH) gene, called circSHPRH, can protect a specific downstream protein from proteasomal degradation, and subsequently exerts its suppressor activity against glioma cells; the corresponding protein (i.e., SHPRH) will ubiquitinate PCNA antigen and inhibits cell proliferation (175).