Furthermore, we found that pancreatic cancer cell lines with HRS may be sensitive to multiple antitumor inhibitors, primarily focusing on PI3K/AKT/mTOR signaling inhibitors (PIK-93, GSK2126458, CAL-101 and rapamycin) and modulators of ATP levels (AZD7762 and thapsigargin), consistent with the finding that PI3K/AKT is highly expressed in pancreatic cancer and promotes tumor metastasis. Here, AKT1 is linked to familial pancreatic carcinoma.