In the past decade, the top 10 keywords in terms of word frequency were “bladder cancer”, “immunotherapy”, “urothelial carcinoma”, “BCG”, “Bacillus Calmette-Guerin”, “programmed death-ligand 1 (PD-L1)”, “chemotherapy”, “urinary bladder neoplasms”, “prognosis”, “programmed death 1 (PD-1)”. The gene discussed is CD274; the disease is urinary bladder carcinoma.