Thus, patients with Ph-like ALL cases are divided into two major classes for therapeutic targeting purposes: ABL class (including ABL1, ABL2, CSF1R, and PDGFRB rearrangements) and JAK pathway activating (including CRLF2, JAK2, or EPOR rearrangements, SH2B3 deletions, and IL7R indels) (Figure 1A). Here, PDGFRB is linked to acute lymphoblastic leukemia.