While this observation warrants detailed molecular studies, it suggests that SIGLEC8 localization might be regulated in a similar fashion as the CD33 form (CD33m) that protects from Late Onset Alzheimer's Disease (LOAD) (Hollingworth et al., 2011) and it corroborates the hypothesis that Siglec receptors might exhibit intracellular functions. This evidence concerns the gene CD33 and early-onset autosomal dominant Alzheimer disease.