ANK3 and schizophrenia: This advantage has been observed in other genes as well, such as MAD1L1 (rs1107592) and TSNARE (rs4976976) heterozygotes who have a decreased risk of schizophrenia (29), and Ank3+/− heterozygous mice which exhibited similar behavioral alterations of reduced anxiety and increased motivation for reward when compared to wild-type Ank3+/+ mice (33).