SIRT1 and major depressive disorder: In a large-scale genome-wide association study (GWAS) of 5,303 Han Chinese women with recurrent and severe major depressive disorder (MDD) and 5,337 healthy female controls, two single-nucleotide polymorphisms (SNPs), rs12415800 in SIRT1 and rs35936514 in LHPP, were significantly associated with MDD (CONVERGE consortium (24)).