CAF-specific HIF-2α-deficient tumors had a significantly lower proportion of myeloid immune cells than CAF-HIF-2α WT tumors and reduction of Arg1, mannose receptor C-type 1 (Mrc1), Cd11b (Itgam), Cd68, and Adgre1 (F4/80) whole tumor gene expression associated with tumor promoting TAMs, suggesting that HIF-2α in CAFs indirectly modulates immunosuppressive TAMs. This evidence concerns the gene MRC1 and neoplasm.