RNA-sequencing of wild-type versus HIF-2α-deficient TAMs in murine breast tumors demonstrated 3 more genes Spint1, IL-10, and Depdc7 were downregulated by HIF-2α knockout and had an identified HIF-2α (not HIF-1α) binding site using previously published ChIP-seq data sets [47]. The gene discussed is SPINT1; the disease is breast neoplasm.