We also found a significant reduction in M2-like Mrc1 mRNA expression in our studies using orthotopic breast tumors in myeloid HIF-2α-deficient mice but significant increases in M2-like Lyve1 and Ym1, suggesting that conclusions of myeloid HIF-2α driving alternative activation in TAMs require further investigation (data not published). The gene discussed is EPAS1; the disease is breast neoplasm.