Myeloid knockout of HIF-1α ameliorated murine dextran sodium sulfate (DSS)-induced colitis while myeloid HIF-2α knockout aggravated colitis by increasing myeloperoxidase (MPO)+ and CD3+FoxP3+ T regulatory cell recruitment deep in the colon with no apparent differences in F4/80+ cell infiltration [86]. Here, EPAS1 is linked to colitis.