EPAS1 and neoplasm: In hypoxia-treated murine bone marrow-derived macrophages (BMDMs) as well as fluorescence-activated cytometry sorted tumor CD11b+ cells, we have shown that HIF-1α or HIF-2α knockout moderately decreased Vegfa mRNA expression [9], suggesting partial redundancy of Vegfa expression by HIF-1α and −2α in TAMs.