Given that deficiency of adenosine A2A receptors in myeloid cells (LysMcre/Adora2aflox/flox) reduces murine melanoma and increased tumor-suppressive MHCII and IL-12 expression in TAMs, HIF-2α may be driving an immunosuppressive, TAM phenotype that promotes tumor progression [161]. The gene discussed is EPAS1; the disease is melanoma.