EPAS1 and myocardial ischemia: Myocyte HIF-2α-deficiency worsened myocardial ischemia-reperfusion injury in comparison to myocyte HIF-1α-deficient mice, and recombinant Areg treatment in HIF-2α-deficient mice was cardioprotective, suggesting that myocyte HIF-2α confers protection in myocardial-reperfusion injury.