CD274 and pneumonitis: Similarly, the PD-1/CTLA-4 plus chemotherapy combination demonstrated an association with pneumonitis [PD-1+chemotherapy: 1.70, 95% CI 1.52-1.91; CTLA-4+chemotherapy: 1.70, 95% CI 1.31-2.20], while PD-L1 combination ICSRs did not show the association.