- Eugenol inhibited the production of IL-6 and IL-10, IL-4 and IL-5, as well as NF-κB pathways, and thereby OVA-induced eosinophilia was guarded from lung cells study (Bachiega et al., 2012).- Eugenol also inhibited TNFα and IL-1β production as well as the signaling NF-κB pathways (ERK1/2 & p38- MAPK /in LPS-stimulated macrophages) (Barboza et al., 2018).- Eugenol enervated the inflammatory response in pig intestinal epithelial cells by dramatically lowering both CXCL8 and TNFα mRNA levels in an LPS-induced inflammatory model (Hui et al., 2020). The gene discussed is CXCL8; the disease is Increased total eosinophil count.