Mao et al. (2019a) demonstrated the induction of ferroptosis in mice models of pilocarpine (Pilo)and pentylenetetrazole (PTZ) kindling-induced seizures (Mao et al., 2019b). Previous indications that ferroptosis is involved in epilepsy were substantiated by hematological findings in children with epilepsy, which showed a consistent increase in 4-hydroxynonenal (4-HNE) and NAPDH oxidase 2 (NOX2), depletion of GSH, and inactivation of GPX4 (Petrillo et al., 2021). The gene discussed is CYBB; the disease is epilepsy.