PTGS2 and epilepsy: Baicalein has also been shown to significantly inhibit epilepsy in an iron chloride (FeCl3)-induced posttraumatic epilepsy mouse model and in ferric ammonium citrate (FAC)-induced HT22 hippocampal neuron cells by decreasing lipid ROS and 4-HNE, downregulating prostaglandin endoperoxide synthase 2 (PTGS2), and inhibiting the expression of 12/15-lipoxygenase (12/15-LOX).