BCL2 and hepatocellular carcinoma: First of all, sinapic acid (2) has strong anticancer activity against various differentiated types of liver cancer cells, and in combination with cisplatin mediates the Bcl-2 assaciated X protein/B cell lymphoma/lewkmia-2 (Bax/Bcl-2) signaling pathway, upregulates LC3 protein expression, and induces hepatocellular carcinoma cell death (Zhao, 2021).